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Molecular Diagnostics and Genomics in Breast Cancer

01.03.2021  -  05.03.2021

Online

Description

Due to the ongoing Coronavirus (COVID-19) crisis, SPCC has made the difficult decision, in agreement with the chairs and sponsors, to commute the event into a virtual meeting.
We deeply regret having to take this decision but we feel that in the current climate this was the only decision possible.
The new dates will be 1-5 March 2021.

The event attendance will be free of charge, but registration is required on the SPCC website.


Chairs 

M.S. Aapro, CH  - J. Gligorov, FR

Foreward

The main common feature of cancer cells is their ability to escape to homeostatic regulation mechanisms of living. In a sense giving them immortality, causing in the absence of treatment the death of the organism, which is their origin. The exponential knowledge of the biology of cancer and the phenomenal capacity of synthesis of new treatments and diagnostic tools have opened up the prospect of a precision medicine in oncology that requires regular and frequent updating of our knowledge.
This knowledge concerns both the intrinsic prognosis of the disease, as the prediction value of therapeutic approaches that in fact becomes increasingly “personalized”. This course aims to take stock of current and future tools that help us optimize the care of patients with breast cancer.

Learning Objectives

  • Improve breast cancer patients care: value and clinical utility of prediction of CT benefit for early stage breast cancer patients
  • Practicing through case discussions

 

 Under the auspices of

 

      

Faculty

INVITED FACULTY
Matti Aapro, Clinique de Genolier, Breast Center, Genolier, CH
Fabrice André, Institut Gustave Roussy, Dept. of Medical Oncology, Villejuif, FR
Anna Batistatou, University of Ioannina, Faculty of Medicine, Ioannina, GR
Francesco Cognetti, Istituto Nazionale Tumori Regina Elena, Dipartimento di Oncologia Medica, Roma, IT
Joseph Gligorov, University Cancer Institute APHP.6 Sorbonne University, Breast Cancer Expert Center, Paris, FR
Nadia Harbeck, LMU University Hospital, Breast Centre, Dept. of Obstetrics and Gynaecology, Munich, DE
Christos Markopoulos, National and Kapodistrian University of Athens, Athens, GR
Riccardo Masetti, Università Cattolica di Roma, Oncology Dpt., Roma, IT
Belinda Nedjai, Queen Mary University of London, Wolfson Institute of Preventive Medicine - Centre for Cancer Prevention, London, GB
Frederique Penault-Llorca, Centre Jean Perrin, Anatomopathology Dpt., Clermont-ferrand Cedex, FR
Giancarlo Pruneri, Fondazione IRCCS - Istituto Nazionale dei Tumori, Pathology Dpt., Milano, IT
Pascal Pujol, Centre Hospitalier Universitaire de Montpellier, Genetics Department, Montpellier Cedex5, FR
Elzbieta Senkus, Medical University of Gdansk, Dept. of Oncology and Radiotherapy, Gdansk, PL
Zsuzsanna Varga, University Hospital Zurich, Pathology Dept., Zurich, CH
Mark Verrill, Northern Centre for Cancer Care, Freeman Hospital, Medical Oncology Dept., Newcastle upon Tyne, GB
Marzia Zambon, Europa Donna - The European Breast Cancer Coalition, Milan, IT

General information

ORGANISING SECRETARIAT

Sharing Progress in Cancer Care
Piazza Indipendenza, 2
6500 Bellinzona – Switzerland

Luis Carvalho
Luis.carvalho@spcc.net  - Tel: +41 91 820 09 58


CME Accreditation and Certificates

Participants will be issued a certificate of attendance (minimum attendance: 75% of the entire course). An online evaluation questionnaire and learning assessment test will need to be completed in order to get  the certificate that will be issued by email. 

Application for CME recognition has been submitted to the Accreditation Council of Oncology in Europe (ACOE) and 8 CME credits have been granted to this event. The American Medical Association (AMA) and the Accreditation Council for Continuous Medical Education (ACCME) designate this type of educational activity for a maximum of 1 AMA PRA category 1 credits per hour of activity.


ACKNOWLEDGEMENTS

Sharing Progress in Cancer Care wishes to extend its appreciation to Daiichi SankyoExact Sciences and Pfizer for having granted their participation and support to the Course.

Terms and Conditions

The event attendance will be free of charge, but registration is required on the SPCC website.

 

Programme

01 March

16:00Welcome and introduction
Matti Aapro, CH - Joseph Gligorov, FR
16:05Optimize patient management in breast cancer: guiding adjuvant treatment decisions
16:20Clinical utility of multigene assays in early breast cancer
 16:20Predictive tests
Christos Markopoulos, GR
 16:30Prognostic tests
16:40Who to test with multigene assay: treatment algorithms – specific patient profiles (lobular; premenopausal CT decisions)
 16:40Clinical perspective
 16:50Next Generation Sequencing
Anna Batistatou, GR
17:00Discussion and Q&A

02 March

16:00Welcome and introduction
16:05Roundtable: Evidence based assessment of diagnostic tests: criteria for a health technology assessment – why outcomes of HTA decisions can be different…?
 16:05The French rationale
 16:15Why NICE accepted?
 16:25Why German authorities accepted?
16:35The essential pathology testing needed for breast cancer, quality control
Anna Batistatou, GR
16:50What tests to ask for and what clinical implications in "TRIPLE NEGATIVE" BrCa
Nadia Harbeck, DE
17:05The patient’s advocacy perspective
Marzia Zambon, IT
17:25Discussion and Q&A

03 March

16:00Welcome and introduction
16:05Group session: Patient Case discussion on multigene assays in early breast cancer: who to test and how to deal with the results?
 16:05Goup 1
Joseph Gligorov, FR - Riccardo Masetti, IT - Elzbieta Senkus, PL - Zsuzsanna Varga, CH
  Case 1: 1 patient 29 years HR+, HER2- pN0 with low-clinical risk
  Case 2: 1 patient 73 years HR+, HER2- pN1 with high-clinical risk
  Case 3: 1 patient 45 years HR+, HER2- pN0 with intermediate-clinical risk
  Case 4: 1 patient 55 years HR+, HER2- pN0 with intermediate-clinical risk
 16:05Group 2
Matti Aapro, CH - Christos Markopoulos, GR - Giancarlo Pruneri, IT
  Case 1: 1 patient 29 years HR+, HER2- pN0 with low-clinical risk
  Case 2: 1 patient 73 years HR+, HER2- pN1 with high-clinical risk
  Case 3: 1 patient 45 years HR+, HER2- pN0 with intermediate-clinical risk
  Case 4: 1 patient 55 years HR+, HER2- pN0 with intermediate-clinical risk
17:05Panellists case discussion summary and Q&A

04 March

16:00Advanced breast cancer (PART1)
16:05DNA Methylation: a useful biomarker for breast cancer diagnosis, prognosis and treatment
Belinda Nedjai, UK
16:25NGS impact or not in breast cancer
16:45Alpelisib what to test
 16:45Clinical positioning
 17:00What to test
Frederique Penault-Llorca, FR
17:15Discussion and Q&A

05 March

16:00Advanced breast cancer (PART2)
16:00Welcome and intruduction
16:05Parp inhibitors what to test
 16:20Clinical implication
16:35Immunotherapy: what to test
 16:35Test
Frederique Penault-Llorca, FR
 16:50Clinical implication
17:05HER-2 alterations not defined as ASCO CAP HER-2 positivity
 17:05Test
Frederique Penault-Llorca, FR
 17:20Clinical implication
Joseph Gligorov, FR
17:35Discussion and Q&A
18:05Closure