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Improving Care of Metastatic Breast Cancer (MBC) Patients in Europe

Request for Proposals (RFP) info downloadable here
Release date: 4th September 2020
To submit your RFP please go to www.cybergrants.com/pfizer/loi


Pfizer will partner with SPCC on an RFP-driven grant-making initiative to provide funding to European healthcare institutions and organizations interested in implementing specific guideline recommendations for improving the quality of breast cancer care in their hospitals, health systems, or cancer care centres.

Goal of the project “Improving care of metastatic breast cancer (MBC) patients in Europe” is to provide funding to European healthcare institutions and organizations interested in implementing specific guideline recommendations or to improve the quality of breast cancer care in their hospitals, health systems or cancer care centres or networks by means of grants based on Requests for Proposals (RFP), through a Pfizer platform. This will be implemented through a two-stage review process.

A Request for Proposals (RFP) will have to be developed and will describe the types of projects eligible for consideration. Project proposals should include elements such as initial assessment of current practice, strategies for implementing improvements into routine care including potentially embedding as a pathway or algorithm in the patient file or Electronic Medical Record (EMR) system, capturing clinical outcomes in the patient file or EMR system and a plan for educating the healthcare professional staff on the updated care plans, and a plan for measuring success such as effectiveness against quality metrics.

This SPCC-led expert panel will review proposals and select the highest quality projects. 

Expert panel reviewers

Matti S. Aapro, Clinique de Genolier - Sharing Progress in Cancer Care (SPCC), Genolier/Bellinzona

Giuseppe Curigliano, European Institute of Oncology, Milan

Lucia Del Mastro, IRCCS Ospedale Policlinico San Martino–University of Genoa

Pascale Dielenseger, Gustave Roussy, Villejuif

Alex Eniu, Riviera-Chablais Vaud-Valais, Rennaz

Joseph Gligorov, University Cancer Institute APHP.6, Sorbonne University, Paris

Nadia Harbeck, University of Munich

Pietro Presti, Sharing Progress in Cancer Care (SPCC), Turin/Bellinzona

Elzbieta Senkus, Medical University of Gdansk

Rosanna Tarricone, Bocconi University, Milan


The RFP project

The intent of the RFP is to encourage European healthcare systems, cancer care centers or networks to submit Letters of Intent (LOIs) describing concepts and ideas for the implementation of strategies that will measurably improve the quality of care of metastatic breast cancer (MBC) patients. Projects should improve the implementation of guideline-based care and use optimal measures to improve care for patients with metastatic breast cancer, where treatment goals focus on improving quality and length of life as there is, to date, no known cure. Multiple factors contribute to the complexity of treating the disease including the need for cross-functional involvement in care; the rapidly changing options for personalizing treatment strategies; managing treatment and disease side effects; communicating with patients, caregivers and family members about quality of life and end-of-life decisions, as well as the many obstacles patients face when living with the disease.

Supporting health care professionals in their efforts to maintain and improve their knowledge, ability, and performance related to treating patients with MBC is critical to improving patient care. The quality of care that health care professionals provide takes place in complex systems that are often in need of analysis and modification to allow for more efficient and effective patient care. In addition, providing resources and education to patients, their caregivers, and family members is crucial to help ensure they are informed and can participate in the shared decision-making process.

Gaps in Clinical Practice


A gap in clinical practice is considered to be the difference between current practice and the optimal standard of care. Gaps are associated with a combination of:

• Clinician factors (e.g. knowledge, competencies, attitudes or preferences);

• Patient factors (e.g. access to care, clinical characteristics, comorbid conditions, preferences, Quality of Life (QOL), work, family);

• Clinician and patient communication (e.g. clinical trial recruitment, genetic counseling, access to genetic testing);

• Health system organization including care processes (integrated breast cancer care vs. practice-based MBC care), resources, availability of all required aspects of care including access to genetic testing.

Gaps in clinical practice may relate to the ability or competencies of the health care professionals themselves, the abilities or competencies of the systems in which they work to promote or allow proper management, or other factors related to the external environment or patient population.
This RFP seeks to provide funding to projects that, ultimately, are aimed at helping health care providers deliver the best treatment to each patient at the optimal time.

Scope of the project


SPCC and Pfizer are committed to funding projects that:

• Bring the heath care team together, including innovative organizations, to understand gaps in practice and develop strategies to improve care/close the gap.

• Further identify quality and performance gaps in the treatment of MBC with deeper analyses and understanding of the gaps and needs of those targeted and/or included in the intervention. These can encompass a broad set of areas.

Needs may include improved provider knowledge regarding clinical aspects (i.e. pathology and mechanism of action and toxicities of treatment choices) and extend to organizational, logistical, as well as technological gaps.

• Facilitate health care systems and providers to engage patients, their caregivers and families in shared decisionmaking.

• Use evidence-based educational strategies that are aligned with the desired results of the intervention.

Areas of interest

1) Optimal treatment strategies for patients with MBC based on patient and tumor characteristics and genetic risk addressing treatment disparities with respect to age/socioeconomic background or setting i.e. patients in a remote setting without access to a reference cancer center/hospital or education level.

2) Delivering optimal treatment regardless of physician disciplines and wherever there is a point of MBC patients contact i.e. primary care (gynaecologists, surgeons).

3) Leveraging a multi-disciplinary team and approach to improve patient quality of MBC delivery of care.

4) Therapy management.

5) Health care professionals, healthcare managers and policymaker education in terms of outcomes research (assessment of QOL, caregiver perspective), assessment of treatment options vs healthcare systems sustainability in order to optimize MBC treatment strategies for patients. This can include incorporation of new technologies to enhance the quality of delivery of healthcare services to MBC patients.

6) Patient education, shared treatment goals, and engagement in decision making.

7) Patient adherence with MBC treatment.

8) Patient reported outcomes in MBC patients.

LOIs addressing topics in addition to those listed above will be considered. A plan for long-term sustainability should be included within the submission.

This RFP is open to investigators from European institutions and networks (members or not of OECI) will be considered as well as professional societies and patient advocacy groups. Collaboration between institutions and across European countries is strongly encouraged in order to foster the interactive sharing of knowledge and expertise, and to utilize the combined strengths of members. Also, partnerships between clinically focused academic centres/departments with centres of health policy, healthcare management and health economics skills are also encouraged. Investigators can be of any health care professional background.

RFP target group

This RFP is open to investigators from European institutions and networks (members or not of OECI) will be considered as well as professional societies and patient advocacy groups. Collaboration between institutions and across European countries is strongly encouraged in order to foster the interactive sharing of knowledge and expertise, and to utilize the combined strengths of members. Also, partnerships between clinically focused academic centres/departments with centres of health policy, healthcare management and health economics skills are also encouraged. Investigators can be of any health care professional background.